Tyrosine sulphation is not required for microvillar expression of intestinal aminopeptidase N

Intestinal, but not hepatic, ChREBP is required for fructose tolerance.

Increased sugar consumption is a risk factor for the metabolic syndrome including obesity, hypertriglyceridemia, insulin resistance, diabetes, and nonalcoholic fatty liver disease (NAFLD). Carbohydrate responsive element-binding protein (ChREBP) is a transcription factor that responds to sugar consumption to regulate adaptive metabolic programs. Hepatic ChREBP is particularly responsive to fruc...

Biosynthesis of intestinal microvillar proteins

The post-translational processing of pig small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured mucosal explants. Exposure of the explants to swainsonine, an inhibitor of Golgi mannosidase II, resulted in the formation of a M,-160000 polypeptide, still sensitive to endo-ffi-N-acetylglucosaminidase H. Swainsonine caused only a moderate inhibition of transport of the enzyme...

is evaluation of hepatitis a immunity required or not?

Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage.

Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes, smooth muscle cells, and keratinocytes while inhibiting the growth of several tumor-derived epithelial cell lines. The epiregulin gene (Ereg) is located on mouse chromosome 5 adjacent to three other epidermal growth ...

Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis

Regulatory T (T(R)) cells are integral to the maintenance of intestinal homeostasis, where an intricate balance between tolerance and immunity must be maintained. Recently, studies have focused on the identification of molecules involved in the function and/or development of T(R) cells. One such molecule, the G-protein coupled receptor Gpr83, has been identified through gene expression analysis...